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S-Isopropylisothiourea hydrobromide is a small-molecule inhibitor targeting nitric oxide synthase (NOS) It is designed to inhibit NOS activity thereby reducing nitric oxide (NO) production and modulating NO-mediated biological processes S-Isopropylisothiourea hydrobromide exerts its biological activity primarily through selective NOS inhibition Based on these pharmacological properties S-Isopropylisothiourea hydrobromide holds research potential in investigating NO-related processes particularly in pathophysiological contexts such as hemorrhagic shock
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IPTU is a potent inhibitor of NOS in vitro but may lack good in vivo efficacy due to poor cellular penetration. The Ki values are 9.8, 22, and 37 nM using purified human iNOS, eNOS, and nNOS, respectively.{1292}
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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JTT 551 is a selective protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Ki values of 0.22 μM for PTP1B and 9.3 μM for TCPTP (T-cell protein tyrosine phosphatase). It can be used in the research of type 2 diabetes mellitus. JTT 551 enhances insulin-induced deoxyglucose uptake in a dose-dependent manner and dose-dependently decreases blood glucose levels in db/db mice. It also significantly reduces triglyceride levels.
Selective PTP1B inhibitor
Enhances insulin-induced deoxyglucose uptake
Decreases blood glucose levels
Reduces triglyceride levels
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Tocopherols are an important class of fat-soluble vitamins, with gamma-tocopherol being the most common form, followed by beta-tocopherol and alpha-tocopherol.
High purity (98.6%)
Liquid form, colorless to light yellow
Soluble in DMSO at 100 mg/mL
Stable for up to 3 years in pure form at -20°C
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Tocopherols are an important class of fat-soluble vitamins, the most common form of which is gamma-tocopherol, followed by beta-tocopherol and alpha-tocopherol.
Important class of fat-soluble vitamins.
Gamma-tocopherol is the most common form.
Includes beta-tocopherol and alpha-tocopherol.
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